I am one of "those" people that avoid the mouse as if it still carryies the bubonic plague. I have gone far out of my way to find ways to minimize my use of it. Here are a few tips for “trapping the mouse.”

Keyboard Keys

• Enter - Pressing the Enter key activates the selected button, option, or object. This includes submitting a form or pushing a button. The enter key can eliminate a lot of pointless clicking.
  
• Space - This can be used to activate the currently selected objcet, from buttons, to checkboxes, to radio buttons.
• Tab - This cycles the selection from button to button and field to field. If pressed in combination with shift, it moves the selection back one field.

Shortcut Keys
Many of the shortcut keys are standard across programs. This, hopefully, makes them easier to remember. Using shortcuts save time because they are more direct links to common functions.
Here are a few of the bare essentials:

• Ctrl+A - Select All
• Ctrl+C - Copy
• Ctrl+N - New
• Ctrl+P - Print
• Ctrl+S - Save
• Ctrl+V - Paste
• Alt+F4 - Exit

Windows Key
The windows key is the ultimate modifier key. It has numerous system level shortcuts to make life faster and easier. My favorites are:

• Win+E - Explorer
• Win+R - Run
• Win+D - Desktop

There are quite a few others, but these are the ones that I use on a regular basis.

Alt+Tab
The best way to quickly switch between applications is with this key combination. Push and hold the Alt key, then press Tab a few times to cycle through the programs that are currently running.

Launchy
"Launchy is a free windows utility designed to help you forget about your start menu, the icons on your desktop, and even your file manager."

I love this program for opening things quickly. It is not just a Start Menu replacement, it's a definite upgrade. The best part is that Launchy is simple:

1. Push the hotkey (of your choice) to open Launchy.
2. Type a few letters in the name of the program you want.
3. Hit enter and your program of choice opens.

Link

Winamp Key Controller
Winamp is my music player of choice (version 2.91 in particular because it does the two things that I want it to: play music and not hog resources). This plug-in lets you designate system wide hot-keys for controlling it. This is particularly handy if you're on a laptop without media keys.
Link